| Item Type | Name |
|
Concept
|
Antibodies, Bacterial
|
|
Concept
|
Antigens, Ly
|
|
Concept
|
Agglutination Tests
|
|
Concept
|
alpha-Fetoproteins
|
|
Concept
|
Abelson murine leukemia virus
|
|
Concept
|
Ampicillin Resistance
|
|
Concept
|
Bone Marrow Cells
|
|
Concept
|
Alleles
|
|
Concept
|
Antibody-Producing Cells
|
|
Concept
|
Antibodies, Anti-Idiotypic
|
|
Concept
|
Histocompatibility Antigens Class II
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Base Sequence
|
|
Concept
|
Autoradiography
|
|
Concept
|
Autoantibodies
|
|
Concept
|
Bone Marrow
|
|
Concept
|
Cell Separation
|
|
Concept
|
Centrifugation, Density Gradient
|
|
Concept
|
Chromosome Deletion
|
|
Concept
|
Chromosome Mapping
|
|
Concept
|
Codon
|
|
Concept
|
Genes, Immunoglobulin
|
|
Concept
|
Genetic Vectors
|
|
Concept
|
Guinea Pigs
|
|
Concept
|
Cosmids
|
|
Concept
|
Choline
|
|
Concept
|
Homozygote
|
|
Concept
|
Immunoglobulin M
|
|
Concept
|
Immune System
|
|
Concept
|
Deoxyuracil Nucleotides
|
|
Concept
|
Dogfish
|
|
Concept
|
Immunoglobulin Constant Regions
|
|
Concept
|
Cytidine
|
|
Concept
|
DNA Mutational Analysis
|
|
Concept
|
DNA, Neoplasm
|
|
Concept
|
DNA, Recombinant
|
|
Concept
|
Electrophoresis, Polyacrylamide Gel
|
|
Concept
|
Hybridomas
|
|
Concept
|
Immunoglobulin A
|
|
Concept
|
Immunity, Active
|
|
Concept
|
Deoxyribonucleases
|
|
Concept
|
Cockayne Syndrome
|
|
Concept
|
DNA-Directed DNA Polymerase
|
|
Concept
|
DNA, Superhelical
|
|
Concept
|
Fibrinogen
|
|
Concept
|
Fibroblasts
|
|
Concept
|
Introns
|
|
Concept
|
Endonucleases
|
|
Concept
|
Enzyme Activation
|
|
Concept
|
Mice, Inbred C3H
|
|
Concept
|
Gene Expression Regulation
|
|
Concept
|
Genes, Switch
|
|
Concept
|
Genes
|
|
Concept
|
Genes, MHC Class II
|
|
Concept
|
Kanamycin Resistance
|
|
Concept
|
Fluorides
|
|
Concept
|
DNA Polymerase III
|
|
Concept
|
Nucleic Acid Hybridization
|
|
Concept
|
Genetic Engineering
|
|
Concept
|
Histological Techniques
|
|
Concept
|
Hematopoietic Stem Cells
|
|
Concept
|
Immune Sera
|
|
Concept
|
Immunoglobulin Heavy Chains
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Herpesvirus 4, Human
|
|
Concept
|
Escherichia coli
|
|
Concept
|
Feedback
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Immunoglobulin Idiotypes
|
|
Concept
|
Immunoglobulin gamma-Chains
|
|
Concept
|
Immunoglobulin J-Chains
|
|
Concept
|
Multigene Family
|
|
Concept
|
Germ Cells
|
|
Concept
|
Goats
|
|
Concept
|
Macrophages
|
|
Concept
|
Isoelectric Point
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Mosaicism
|
|
Concept
|
Peyer's Patches
|
|
Concept
|
Mice, Inbred AKR
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Models, Genetic
|
|
Concept
|
Exodeoxyribonucleases
|
|
Concept
|
Poultry
|
|
Concept
|
Immunoglobulin Switch Region
|
|
Concept
|
Immunoglobulin Variable Region
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Repetitive Sequences, Nucleic Acid
|
|
Concept
|
Mutation
|
|
Concept
|
Cricetinae
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Phosphorylcholine
|
|
Concept
|
Nucleosomes
|
|
Concept
|
Nucleic Acid Conformation
|
|
Concept
|
Oocytes
|
|
Concept
|
Pedigree
|
|
Concept
|
Microcirculation
|
|
Concept
|
Microscopy, Electron
|
|
Concept
|
Spermatids
|
|
Concept
|
Myeloma Proteins
|
|
Concept
|
Fetus
|
|
Concept
|
Plasma Cells
|
|
Concept
|
Plasmids
|
|
Concept
|
Globins
|
|
Concept
|
Immunoglobulin G
|
|
Concept
|
Immunization, Passive
|
|
Concept
|
Immunoelectrophoresis
|
|
Concept
|
Immunoglobulin Joining Region
|
|
Concept
|
RNA-Directed DNA Polymerase
|
|
Concept
|
Puromycin
|
|
Concept
|
Receptors, Antigen, B-Cell
|
|
Concept
|
Xeroderma Pigmentosum
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte
|
|
Concept
|
Regulatory Sequences, Nucleic Acid
|
|
Concept
|
RNA Splicing
|
|
Concept
|
Leukemia, B-Cell
|
|
Concept
|
Spermatogonia
|
|
Concept
|
Hemocyanins
|
|
Concept
|
Sheep
|
|
Concept
|
Humans
|
|
Concept
|
Immunization
|
|
Concept
|
Tritium
|
|
Concept
|
Immunoglobulin alpha-Chains
|
|
Concept
|
Immunoglobulin lambda-Chains
|
|
Concept
|
Immunoglobulin mu-Chains
|
|
Concept
|
Umbilical Veins
|
|
Concept
|
Terminator Regions, Genetic
|
|
Concept
|
Immunoglobulin Class Switching
|
|
Concept
|
Lymphoid Tissue
|
|
Concept
|
Codon, Terminator
|
|
Concept
|
Gene Rearrangement
|
|
Concept
|
Gene Rearrangement, T-Lymphocyte
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Chromosomes, Artificial, Bacterial
|
|
Concept
|
Deoxyribonucleases, Type II Site-Specific
|
|
Concept
|
B-Lymphocyte Subsets
|
|
Concept
|
Mice, Inbred DBA
|
|
Concept
|
TATA Box
|
|
Concept
|
3T3 Cells
|
|
Concept
|
Lymph Nodes
|
|
Concept
|
Microinjections
|
|
Concept
|
Microscopy
|
|
Concept
|
Multiple Myeloma
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte, Heavy Chain
|
|
Concept
|
Gene Rearrangement, B-Lymphocyte, Light Chain
|
|
Concept
|
Scientific Misconduct
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Sequence Alignment
|
|
Concept
|
Sequence Analysis, DNA
|
|
Concept
|
Methionine
|
|
Concept
|
Methylation
|
|
Concept
|
Genes, Reporter
|
|
Concept
|
National Institutes of Health (U.S.)
|
|
Concept
|
Point Mutation
|
|
Concept
|
Interferon-alpha
|
|
Concept
|
Bacteriophage P1
|
|
Concept
|
Gene Deletion
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
RNA Editing
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Gene Expression Regulation, Developmental
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Chemokines
|
|
Concept
|
Interferon-Stimulated Gene Factor 3
|
|
Concept
|
Interferon-Stimulated Gene Factor 3, gamma Subunit
|
|
Concept
|
Inhibitor of Apoptosis Proteins
|
|
Concept
|
Models, Immunological
|
|
Concept
|
Transgenes
|
|
Concept
|
BRCA1 Protein
|
|
Concept
|
Mice, Inbred MRL lpr
|
|
Concept
|
Fanconi Anemia Complementation Group D2 Protein
|
|
Concept
|
Fas Ligand Protein
|
|
Concept
|
Artificial Gene Fusion
|
|
Concept
|
Base Pair Mismatch
|
|
Concept
|
Lymphocyte Count
|
|
Concept
|
CpG Islands
|
|
Concept
|
Nucleic Acid Denaturation
|
|
Concept
|
Embryonic Development
|
|
Concept
|
Chromatin Assembly and Disassembly
|
|
Concept
|
Chromatin Immunoprecipitation
|
|
Concept
|
Proto-Oncogene Proteins c-bcl-2
|
|
Concept
|
5' Untranslated Regions
|
|
Concept
|
DNA Footprinting
|
|
Concept
|
Genes, bcl-2
|
|
Concept
|
Dendritic Cells, Follicular
|
|
Concept
|
Gene Expression Profiling
|
|
Concept
|
TATA-Box Binding Protein
|
|
Concept
|
bcl-X Protein
|
|
Concept
|
Saccharomyces cerevisiae Proteins
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Mice
|
|
Concept
|
Ribonucleases
|
|
Concept
|
Interferon Regulatory Factors
|
|
Concept
|
Rats
|
|
Concept
|
Uracil
|
|
Concept
|
Uridine
|
|
Concept
|
Spleen
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Temperature
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Genes, myc
|
|
Concept
|
Lymphoma, B-Cell
|
|
Concept
|
Genes, RAG-1
|
|
Concept
|
Transfection
|
|
Concept
|
Blotting, Southern
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Gene Expression Regulation, Enzymologic
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
DNA Methylation
|
|
Concept
|
Leukocyte Common Antigens
|
|
Concept
|
Gene Silencing
|
|
Concept
|
Chromosomes, Artificial
|
|
Concept
|
Gene Targeting
|
|
Concept
|
Germinal Center
|
|
Concept
|
Microsatellite Repeats
|
|
Concept
|
Gene Knock-In Techniques
|
|
Concept
|
Antibodies
|
|
Concept
|
Antibody Diversity
|
|
Concept
|
Binding, Competitive
|
|
Concept
|
Blood Group Antigens
|
|
Concept
|
Chickens
|
|
Concept
|
Chromatin
|
|
Concept
|
Chromosomes
|
|
Concept
|
Cloning, Molecular
|
|
Concept
|
Crosses, Genetic
|
|
Concept
|
Cytosine
|
|
Concept
|
Deoxycytidine
|
|
Concept
|
Deoxyribonuclease I
|
|
Concept
|
DNA Restriction Enzymes
|
|
Concept
|
DNA, Single-Stranded
|
|
Concept
|
Electrophoresis, Agar Gel
|
|
Concept
|
Enhancer Elements, Genetic
|
|
Concept
|
Erythrocytes
|
|
Concept
|
Hemagglutination Tests
|
|
Concept
|
Hemolytic Plaque Technique
|
|
Concept
|
Immunoglobulins
|
|
Concept
|
Immunoglobulin kappa-Chains
|
|
Concept
|
Immunoglobulin Light Chains
|
|
Concept
|
Kinetics
|
|
Concept
|
Genetic Linkage
|
|
Concept
|
Lymphocyte Activation
|
|
Concept
|
Lymphocytes
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Microscopy, Phase-Contrast
|
|
Concept
|
Nucleotide Mapping
|
|
Concept
|
Radiation Effects
|
|
Concept
|
Recombinant Fusion Proteins
|
|
Concept
|
Spermatozoa
|
|
Concept
|
T-Lymphocytes
|
|
Concept
|
Thymus Gland
|
|
Concept
|
Translocation, Genetic
|
|
Concept
|
Umbilical Cord
|
|
Concept
|
Restriction Mapping
|
|
Concept
|
Deoxyribonuclease BamHI
|
|
Concept
|
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
|
|
Concept
|
Transcriptional Activation
|
|
Concept
|
Immunophenotyping
|
|
Concept
|
Mutagenesis, Insertional
|
|
Concept
|
Mice, SCID
|
|
Concept
|
Sequence Analysis
|
|
Concept
|
5-Methylcytosine
|
|
Academic Article
|
N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
|
|
Academic Article
|
Identification and characterization of the murine Rag1 promoter.
|
|
Academic Article
|
Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
|
|
Academic Article
|
B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
|
|
Academic Article
|
The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
|
|
Academic Article
|
Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
|
|
Academic Article
|
Cis-acting sequences that affect somatic hypermutation of Ig genes.
|
|
Academic Article
|
Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
|
|
Academic Article
|
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
|
|
Academic Article
|
A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcript.
|
|
Academic Article
|
Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
|
|
Academic Article
|
The role of DNA repair in somatic hypermutation of immunoglobulin genes.
|
|
Academic Article
|
Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
|
|
Academic Article
|
Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
|
|
Academic Article
|
Effects of sequence and structure on the hypermutability of immunoglobulin genes.
|
|
Academic Article
|
Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
|
|
Academic Article
|
A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
|
|
Academic Article
|
Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
|
|
Academic Article
|
Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
|
|
Academic Article
|
Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
|
|
Academic Article
|
Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.
|
|
Academic Article
|
Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain.
|
|
Academic Article
|
AID in somatic hypermutation and class switch recombination.
|
|
Academic Article
|
Factors affecting the rearrangement efficiency of an Ig test gene.
|
|
Academic Article
|
The activation-induced cytidine deaminase (AID) efficiently targets DNA in nucleosomes but only during transcription.
|
|
Academic Article
|
Somatic hypermutation: processivity of the cytosine deaminase AID and error-free repair of the resulting uracils.
|
|
Academic Article
|
Brca1 in immunoglobulin gene conversion and somatic hypermutation.
|
|
Academic Article
|
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice.
|
|
Academic Article
|
Analysis of somatic mutations in kappa transgenes.
|
|
Academic Article
|
Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.
|
|
Academic Article
|
The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
|
|
Academic Article
|
Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.
|
|
Academic Article
|
Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
|
|
Academic Article
|
Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
|
|
Academic Article
|
Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
|
|
Academic Article
|
Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
|
|
Academic Article
|
Rearrangement of immunoglobulin genes.
|
|
Academic Article
|
Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
|
|
Academic Article
|
Synthesis of specific RNA molecules during immune response in the mouse spleen.
|
|
Academic Article
|
Immunoglobulin genes in DNA restriction fragments.
|
|
Academic Article
|
Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
|
|
Academic Article
|
Somatic mutation of immunoglobulin light-chain variable-region genes.
|
|
Academic Article
|
Nucleosome stability dramatically impacts the targeting of somatic hypermutation.
|
|
Academic Article
|
Association of two different repetitive DNA elements near immunoglobulin light chain genes.
|
|
Academic Article
|
Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
|
|
Academic Article
|
Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
|
|
Academic Article
|
Transgenic mice with immunoglobulin genes.
|
|
Academic Article
|
The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
|
|
Academic Article
|
Heterogeneity of the 3' portion of sequences related to immunoglobulin kappa-chain mRNA.
|
|
Academic Article
|
Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
|
|
Academic Article
|
Evolution of mouse immunoglobulin lambda genes.
|
|
Academic Article
|
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
|
|
Academic Article
|
Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
|
|
Academic Article
|
Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications.
|
|
Academic Article
|
Molecular aspects of somatic hypermutation of immunoglobulin genes.
|
|
Academic Article
|
The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
|
|
Academic Article
|
The transcription factor Spi-B is not required for somatic hypermutation.
|
|
Academic Article
|
Steps in the generation of autoantibodies.
|
|
Academic Article
|
Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
|
|
Academic Article
|
The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
|
|
Academic Article
|
Expression of immunoglobulin genes in transgenic mice and transfected cells.
|
|
Academic Article
|
High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
|
|
Academic Article
|
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
|
|
Academic Article
|
B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
|
|
Academic Article
|
Pre-B cells in kappa-transgenic mice.
|
|
Academic Article
|
High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
|
|
Academic Article
|
Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
|
|
Academic Article
|
Evidence for multiple immunoglobulin genes.
|
|
Academic Article
|
Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
|
|
Academic Article
|
Dissent on forensic evidence.
|
|
Academic Article
|
Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.
|
|
Concept
|
MEF2 Transcription Factors
|
|
Grant
|
Molecular and Cellular Biology Training
|
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
|
Grant
|
CONTROL OF IMMUNOGLOBULIN SYNTHESIS
|
|
Grant
|
Mechanism of Immunoglobulin Hypermutation
|
|
Grant
|
AID in somatic mutation of immunoglobulin genes
|
|
Grant
|
Mechanism of Immunoglobulin Hypermutation
|
|
Grant
|
Identification of the DNA methylation/chromatin modifier Ssm1
|
|
Grant
|
EXPRESSION OF IMMUNOGLOBULIN GENES
|